Retinitis pigmentosa is a rare and hereditary neurodegenerative disease which causes vision loss due to the death of photoreceptors in the retina, and for which there is currently no treatment. The research group at the Universidad CEU Cardenal Herrera on Therapeutic Strategies for Ocular Pathologies, headed by professor María Miranda Sanz, had already tested in a previous study the efficiency of progesterone to ameliorate the death of photoreceptor cells in the retina caused by this disease. Now, in a new project published in the scientific journal Frontiers in Pharmacology, they have observed a higher protective effect of progesterone when combined with a strong antioxidant: lipoic acid.
As highlighted by doctor María Miranda, professor at the CEU UCH and main researcher of the group, “in this new study we verified that both progesterone and the lipoic acid are separately able to protect photoreceptors in the retina from cell death, but their simultaneous application provides even better results than individually. These results, obtained in animal models, administering both substances orally, could be the basis for developing future treatments to ameliorate the eyesight deterioration caused by retinitis pigmentosa. There is currently no treatment for a disease which represents half of those that degenerate the retina around the world.”
Antioxidant and anti-inflammatory mechanism
Even though the cause of retinitis pigmentosa is genetic, the evolution of the disease and the resulting eyesight loss may be related to oxidative stress factors and inflammation. These factors can be ameliorated on one hand by the progesterone hormone, which has shown its neuroprotective efficiency in several studies, including the one previously carried out by doctor Miranda and her team also on retinosis.
On the other hand, lipoic acid is considered a strong antioxidant with anti-inflammatory properties, able to reduce oxidative stress in the retina, as have also determined previous studies, including another one headed by professor Miranda. “This is why we decided to test the possible synergetic effects when combining progesterone and lipoic acid in this new study, to ameliorate the death of photoreceptors in the retina.”
Professor María Miranda Sanz, coordinator of the Degree in Optics and Optometry at the CEU UCH, is the main researcher of the “Therapeutic strategies in ocular pathologies” group, mainly dedicated to searching for new therapies for degenerative diseases that affect the visual system such as retinitis pigmentosa and diabetic retinopathy. In this new study on progesterone and lipoic acid, professor María Miranda has headed the team comprised of CEU UCH professors Rosa López-Pedrajas, Teresa Olivar and Dolores Silvestre, along with researchers Dolores Tania Ramírez Lamelas, clinical project manager from BCN Peptides in Barcelona; Soledad Benlloch-Navarro, and CEU UCH doctorate student Roberto Gimeno-Hernández.
More information on the “Lipoic Acid and Progesterone Alone or in Combination Ameliorate Retinal Degeneration in an Experimental Model of Hereditary Retinal Degeneration” is available on the Frontiers in Pharmacology website: https://www.frontiersin.org/articles/10.3389/fphar.2018.00469/full